Sting1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em1Cya
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6762204
• Synonyms: Sting1^em1Cgen, Sting1^em1cyagen, Tmem173^tm1cyagen
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeted exons 2 to 8 for deletion. (J:310336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 49 strains or lines available

References

• Original: J:310336 Bi X, et al., Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability. Adv Sci (Weinh). 2021 Mar;8(5):2002738
• All: 3 reference(s)