Tg(Myh6-ESRRG)L3Javi
Transgene Detail

Summary

• Symbol: Tg(Myh6-ESRRG)L3Javi
• Name: transgene insertion L3, Josep A Villena
• MGI ID: MGI:6763949
• Synonyms: L3 hERR-Tg
• Transgene: Tg(Myh6-ESRRG)L3Javi Location: unknown
• Alliance: Tg(Myh6-ESRRG)L3Javi page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ESRRG)L3Javi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ESRRG (2104)

  Esrrg

  (MGI:1347056)

• Mutation details: This transgene consists of the alpha-myosin heavy chain promoter driving the expression of the human ERRG (hERRgamma) containing two Flag epitopes in the 5' region. Four founder lines L3, L6, L7, and L10 with varying expression levels and specificity were established. L3 line exhibited the highest level of cardiac-specific expression. (J:310470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:310470 Lasheras J, et al., Cardiac-Specific Overexpression of ERRgamma in Mice Induces Severe Heart Dysfunction and Early Lethality. Int J Mol Sci. 2021 Jul 28;22(15)
• All: 1 reference(s)