Pdpk1^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pdpk1^em1Gpt
• Name: 3-phosphoinositide dependent protein kinase 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6765435
• Synonyms: PDK1^flox
• Gene: Pdpk1 Location: Chr17:24292654-24369898 bp, - strand Genetic Position: Chr17, 12.23 cM, cytoband A3.3
• Alliance: Pdpk1^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 2 through 7. (J:310893)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpk1 Mutation: 138 strains or lines available

References

• Original: J:310893 Xiao D, et al., PDK1 is important lipid kinase for RANKL-induced osteoclast formation and function via the regulation of the Akt-GSK3beta-NFATc1 signaling cascade. J Cell Biochem. 2020 Nov;121(11):4542-4557
• All: 2 reference(s)