Ccr8^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccr8^em1Bcgen
• Name: C-C motif chemokine receptor 8; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:6771471
• Synonyms: Ccr8^fl
• Gene: Ccr8 Location: Chr9:119921199-119923972 bp, + strand Genetic Position: Chr9, 71.39 cM, cytoband F4
• Alliance: Ccr8^em1Bcgen page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting generated a floxed allele. (J:311437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr8 Mutation: 39 strains or lines available

References

• Original: J:311437 Liu SS, et al., The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021 Sep 14;54(9):2042-2056.e8
• All: 1 reference(s)