Dyrk1atm1.1Ics
Targeted Allele Detail
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Symbol: |
Dyrk1atm1.1Ics |
Name: |
dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1.1, Mouse Clinical Institute |
MGI ID: |
MGI:6783454 |
Gene: |
Dyrk1a Location: Chr16:94370869-94496376 bp, + strand Genetic Position: Chr16, 55.3 cM
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Alliance: |
Dyrk1atm1.1Ics page
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Germline Transmission: |
Earliest citation of germline transmission:
J:311493
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Parent Cell Line: |
BD10 (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted into intron 7 and an FRT site flanked neomycin resistance gene cassette and second loxP site were inserted into intron 7. The neo cassette was removed through subsequent Flp-mediated recombination, leaving exon 7 floxed. Mutations in the human ortholog are associated with autosomal dominant mental retardation 7 (MRD7).
(J:311493)
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Original: |
J:311493 Brault V, et al., Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome. PLoS Genet. 2021 Sep;17(9):e1009777 |
All: |
2 reference(s) |
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