Otulin^tm1.1Ivdi
Targeted Allele Detail

Summary

• Symbol: Otulin^tm1.1Ivdi
• Name: OTU deubiquitinase with linear linkage specificity; targeted mutation 1.1, Ivan Dikic
• MGI ID: MGI:6814691
• Synonyms: Fam105b^f, Otulin^f
• Gene: Otulin Location: Chr15:27606005-27630793 bp, - strand Genetic Position: Chr15, 10.31 cM
• Alliance: Otulin^tm1.1Ivdi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314183
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 3. The selection cassette was removed via Flp-mediated recombination leaving exon 3 floxed. (J:314183)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otulin Mutation: 22 strains or lines available

References

• Original: J:314183 van Wijk SJL, et al., Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. Nat Microbiol. 2017 May 8;2:17066
• All: 2 reference(s)