Plcg1^tm1.1Suh
Targeted Allele Detail

Summary

• Symbol: Plcg1^tm1.1Suh
• Name: phospholipase C, gamma 1; targeted mutation 1.1, P-G Suh
• MGI ID: MGI:6818632
• Synonyms: Plcg1^lox
• Gene: Plcg1 Location: Chr2:160573230-160617680 bp, + strand Genetic Position: Chr2, 80.97 cM
• Alliance: Plcg1^tm1.1Suh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263481
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using homologous recombination in ES cells, a loxP site was inserted upstream of exon 3 and a 3' loxP site with FRT flanked neo selection cassette was inserted downstream of exon 5. The neo cassette was removed by crossing F1 generation mice to with protamine-Flp mice. (J:263481)

Tumor Data

List all tumor models in MMHCdb carrying Plcg1^tm1.1Suh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg1 Mutation: 48 strains or lines available

References

• Original: J:263481 Yang YR, et al., Forebrain-specific ablation of phospholipase Cgamma1 causes manic-like behavior. Mol Psychiatry. 2017 Oct;22(10):1473-1482
• All: 5 reference(s)