Mbd2^em1Wgcy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mbd2^em1Wgcy
• Name: methyl-CpG binding domain protein 2; endonuclease-mediated mutation 1, Cong-Yi Wang
• MGI ID: MGI:6825813
• Synonyms: Mbd2^flox
• Gene: Mbd2 Location: Chr18:70701260-70759202 bp, + strand Genetic Position: Chr18, 44.54 cM
• Alliance: Mbd2^em1Wgcy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR/Cas9 technology was used to flank exon 2 with loxP sites. (J:314537)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd2 Mutation: 21 strains or lines available

References

• Original: J:314537 Wang Y, et al., MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program. Sci Adv. 2021 Jan;7(1)
• All: 1 reference(s)