Egln2^tm1Jomy
Targeted Allele Detail

Summary

• Symbol: Egln2^tm1Jomy
• Name: egl-9 family hypoxia-inducible factor 2; targeted mutation 1, Johanna Myllyharju
• MGI ID: MGI:6831625
• Gene: Egln2 Location: Chr7:26858083-26866227 bp, - strand Genetic Position: Chr7, 15.83 cM
• Alliance: Egln2^tm1Jomy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314943
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced exon 3, which encodes the two catalytically essential amino acids (H309 and D311) required for iron binding, with a floxed neomycin resistance cassette. (J:314943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln2 Mutation: 18 strains or lines available

References

• Original: J:314943 Ullah K, et al., Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-kappaB and p53 signaling pathways. Sci Rep. 2017 Dec 8;7(1):17220
• All: 2 reference(s)