Tmem41b^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem41b^em1Cya
• Name: transmembrane protein 41B; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6838393
• Synonyms: Tmem41b^em1Cgen
• Gene: Tmem41b Location: Chr7:109571394-109586136 bp, - strand Genetic Position: Chr7, 57.69 cM
• Alliance: Tmem41b^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 4779 bp deletion encompassing a genomic region spanning exons 2 -5. In heterozygous mice liver mRNA levels are about 60% lower compared to wild-type controls. (J:316472)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem41b Mutation: 19 strains or lines available

References

• Original: J:316472 Sun L, et al., Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication. PLoS Pathog. 2021 Dec;17(12):e1010113
• All: 1 reference(s)