Tg(CAG-TNFRSF14*Y61A)23Hgh
Transgene Detail

Summary

• Symbol: Tg(CAG-TNFRSF14*Y61A)23Hgh
• Name: transgene insertion 23, Homayon Ghiasi
• MGI ID: MGI:6850608
• Synonyms: HVEM^hY23A
• Transgene: Tg(CAG-TNFRSF14*Y61A)23Hgh Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(CAG-TNFRSF14*Y61A)23Hgh page

Transgene origin

• Strain of Origin: B6.129P2-Tnfrsf14^tm1Kpf

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-TNFRSF14*Y61A)23Hgh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNFRSF14 (8764)

  Tnfrsf14

  (MGI:2675303)

  Y61A mutation

• Mutation details: The transgene contains the CAG promoter driving ubiquitous expression of the human sequence with the amino acid substitution of tyrosine to alanine at position 61 (Y61A in uniport Q92956; also known as the Y23A mutation). Lines 23 was generated. (J:304481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:304481 Tormanen K, et al., Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM(-/-) Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D. J Virol. 2020 Jul 30;94(16)
• All: 1 reference(s)