Ace2^em1(ACE2)Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1(ACE2)Mbp
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:6856620
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1(ACE2)Mbp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ace2^em1(ACE2)Mbp expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: CRISPR-targeting inserted the human DNA consisting of 5'UTR, coding sequence (exons 2-19) fused to mouse 3'UTR replacing the endogenous gene stretching from the 5'UTR to the starting ATG in exon 2. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 2 reference(s)