Dpp4^em1(DPP4)Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dpp4^em1(DPP4)Mbp
• Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:6856706
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^em1(DPP4)Mbp page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Dpp4^em1(DPP4)Mbp expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: CRISPR-targeting inserted exons 2-26 of human DPP4 in-frame into exon 2 of the mouse gene. The insert contains four silent mutations in the coding sequence to prevent CRISPR RNP re-cleavage (see HGVS nomenclature below); it uses the human 3' UTR to terminate transcription and to prevent potential downstream splicing or RNP re-cleavage. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 73 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)