Cxcr2tm1(CXCR2)Rale
Targeted Allele Detail
|
Symbol: |
Cxcr2tm1(CXCR2)Rale |
Name: |
C-X-C motif chemokine receptor 2; targeted mutation 1, Richard A Lerner |
MGI ID: |
MGI:6865788 |
Synonyms: |
hCXCR2 |
Gene: |
Cxcr2 Location: Chr1:74193153-74200405 bp, + strand Genetic Position: Chr1, 38.41 cM
|
Alliance: |
Cxcr2tm1(CXCR2)Rale page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:319853
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
C57BL/6
|
|
Allele Type: |
|
Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Cxcr2tm1(CXCR2)Rale expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CXCR2 (3579) |
|
|
|
|
|
Mutation details: The mouse Cxcr2 coding sequence was replaced with the human CXCR2 coding DNA sequence via homologous recombination.
(J:319853)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Cxcr2 Mutation: |
31 strains or lines available
|
|
Original: |
J:319853 Shi X, et al., Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms. Nat Commun. 2021 May 5;12(1):2547 |
All: |
1 reference(s) |
|