Gt(ROSA)26Sor^{tm1.1(GSDMB_i2,-EGFP)Gmbu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(GSDMB_i2,-EGFP)Gmbu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Gema Moreno-Bueno
• MGI ID: MGI:7256400
• Synonyms: GB2⁺, R26-GB2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(GSDMB_i2,-EGFP)Gmbu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321835
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A loxP-flanked PGK-neomycin-STOP cassette, the HA-tagged human Gasdermin B isoform 2, IRES, and EGFP were inserted into the locus. Cre-mediated recombination removed the neomycin STOP cassette. (J:321835)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1.1(GSDMB_i2,-EGFP)Gmbu}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:321835 Sarrio D, et al., Gasdermin-B Pro-Tumor Function in Novel Knock-in Mouse Models Depends on the in vivo Biological Context. Front Cell Dev Biol. 2022;10:813929
• All: 1 reference(s)