Trp63^tm1.1Gml
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1.1Gml
• Name: transformation related protein 63; targeted mutation 1.1, Gerry Melino
• MGI ID: MGI:7258079
• Synonyms: delta13p63
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1.1Gml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300878
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed exon 13. Cre-mediated recombination removed exon 13. This allele only expresses isoform beta. (J:300878)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:300878 Lena AM, et al., The p63 C-terminus is essential for murine oocyte integrity. Nat Commun. 2021 Jan 15;12(1):383
• All: 1 reference(s)