Rela^tm2.1Alex
Targeted Allele Detail

Summary

• Symbol: Rela^tm2.1Alex
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 2.1, Alexander Hoffman
• MGI ID: MGI:7258316
• Synonyms: RelA^mVenus, Rela^tm1.1Itl, RelA^V
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm2.1Alex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321300
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a monomeric Venus (mVenus) reporter gene upstream of the start codon. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:321300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 26 strains or lines available

References

• Original: J:321300 Adelaja A, et al., Six distinct NFkappaB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 2021 May 11;54(5):916-930.e7
• All: 2 reference(s)