Ripk1^em2Jhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ripk1^em2Jhan
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; endonuclease-mediated mutation 2, Jiahuai Han
• MGI ID: MGI:7258412
• Synonyms: Ripk1^delta
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^em2Jhan page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: Using an sgRNA (targeting CCCGAAGCCTCCGCTGTCT) and an ssODN template with CRISPR/Cas9 technology, a 6 bp sequence was deleted (c.81_86delCTTCGG), resulting in the deletion of two highly conserved amino acids, F28 and G29, from the P-loop of the N-terminal kinase domain of the encoded protein. (J:309361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 31 strains or lines available

References

• Original: J:309361 Zhang Y, et al., A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5. PLoS Biol. 2021 Aug;19(8):e3001304
• All: 1 reference(s)