Tg(TcrbM38)330Biat
Transgene Detail

Summary

• Symbol: Tg(TcrbM38)330Biat
• Name: transgene insertion 330, Biomodels Austria
• MGI ID: MGI:7263355
• Synonyms: Mini, Tg(Tcrb)330Biat
• Transgene: Tg(TcrbM38)330Biat Location: unknown
• Alliance: Tg(TcrbM38)330Biat page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcrbM38)330Biat expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcrb (MGI:98578)	Expresses a Tcrb clone specific for the M38-derived epitope of MCMV

• Mutation details: This transgene expresses a Tcrb clone specific for the M38-derived epitope of MCMV. The "Mini" mouse is transgenic for the rearranged hybridoma Tcrb chain only, which was expressed by nearly 100% of the CD8 T cells, while the Tcra chain is of endogenous origin. This increases the percentage of nave M38-specific CD8 T cells from undetectable levels in C57BL/6 mice to 10% of the total. (J:183174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:183174 Torti N, et al., Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog. 2011 Oct;7(10):e1002313
• All: 3 reference(s)