Gnb1^em2Frk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gnb1^em2Frk
• Name: guanine nucleotide binding protein (G protein), beta 1; endonuclease-mediated mutation 2, Wayne N Frankel
• MGI ID: MGI:7266713
• Synonyms: Gnb1^D76G
• Gene: Gnb1 Location: Chr4:155575818-155643726 bp, + strand Genetic Position: Chr4, 86.17 cM
• Alliance: Gnb1^em2Frk page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 genome editing is used to create an amino acid substitution at position 76 (aspartic acid to glycine, GAT to GGC, D76G) as well as an unintended silent mutation, S74S (TCT to TCC). (J:101977)

Tumor Data

List all tumor models in MMHCdb carrying Gnb1^em2Frk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gnb1 Mutation: 61 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)