Nebl^tm1(cre)Chen
Targeted Allele Detail

Summary

• Symbol: Nebl^tm1(cre)Chen
• Name: nebulette; targeted mutation 1, Ju Chen
• MGI ID: MGI:7277813
• Gene: Nebl Location: Chr2:17348720-17736275 bp, - strand Genetic Position: Chr2, 12.43 cM, cytoband A2
• Alliance: Nebl^tm1(cre)Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235199
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Nebl^tm1(cre)Chen expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nebl (MGI:1921353)

• Mutation details: The targeting construct replaced exon 1 with a cre recombinase gene and FRT-flanked neomycin resistance cassette. (J:235199)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nebl (mouse) Summary of all recombinase alleles driven by Nebl. Alliance mouse Nebl gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nebl Mutation: 68 strains or lines available

References

• Original: J:235199 Mastrototaro G, et al., Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15;107(2):216-25
• All: 1 reference(s)