Igs2^{em23(CAG-EGFR*T790M*L858R)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em23(CAG-EGFR*T790M*L858R)Gpt}
• Name: intergenic site 2; endonuclease-mediated mutation 23, GemPharmatech Co., Ltd
• MGI ID: MGI:7300636
• Synonyms: Igs2^{em1Cin(CAG-LSL-EGFR(T790M L858R))}
• Gene: Igs2 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em23(CAG-EGFR*T790M*L858R)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em23(CAG-EGFR*T790M*L858R)Gpt} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

• Mutation details: CRISPR-targeting inserted a CAG promoter, floxed STOP cassette, and human gene coding sequence with mutation that results in the amio acid substitution of threonine with methionine at position 790 (T790M) and leucine with arginine at position 858 (L858R). (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 71 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)