Eprs1^em1Pyao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eprs1^em1Pyao
• Name: glutamyl-prolyl-tRNA synthetase 1; endonuclease-mediated mutation 1, Peng Yao
• MGI ID: MGI:7314836
• Synonyms: Eprs gKO
• Gene: Eprs1 Location: Chr1:185095241-185160557 bp, + strand Genetic Position: Chr1, 89.5 cM, cytoband H4-H6
• Alliance: Eprs1^em1Pyao page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 endonuclease-mediated genome editing was used to insert tandem stop codons and a frame-shifting adenosine residue (UAAUAAA) into exon 3 resulting in a null allele. (J:326579)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eprs1 Mutation: 82 strains or lines available

References

• Original: J:326579 Wu J, et al., Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis. Circ Res. 2020 Aug 28;127(6):827-846
• All: 1 reference(s)