Nfe2l2^em1Mmaj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nfe2l2^em1Mmaj
• Name: nuclear factor, erythroid derived 2, like 2; endonuclease-mediated mutation 1, Michael B Major
• MGI ID: MGI:7330326
• Synonyms: Nfe2l2^E79Q
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^em1Mmaj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 genome editing technology, LOX-STOP-LOX (LSL) cassette replaced the first intron 180 bp upstream of a modified Nfe2l2 exon 2, which included the E79Q mutation. (J:299778)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 90 strains or lines available

References

• Original: J:299778 Bowman BM, et al., A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. J Pathol. 2020 Oct;252(2):125-137
• All: 3 reference(s)