Tg(DMD*)35del52Lumc
Transgene Detail

Summary

• Symbol: Tg(DMD*)35del52Lumc
• Name: transgene insertion 35del52, Leiden University Medical Centre
• MGI ID: MGI:7333113
• Synonyms: del52hDMD/mdx#35, hDMDdel52-null
• Transgene: Tg(DMD*)35del52Lumc Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Tg(DMD*)35del52Lumc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257449
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: STOCK Tg(DMD)72Thoen Dmd^mdx/Lumc

Mutation description

• Allele Type: Targeted (No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct deleted exon 52 from both copies of the transgene. Loss of exon 52 results in the loss of DMD protein expression. (J:257449)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:257449 Veltrop M, et al., A dystrophic Duchenne mouse model for testing human antisense oligonucleotides. PLoS One. 2018;13(2):e0193289
• All: 2 reference(s)