Unc5b^tm1.1Slac
Targeted Allele Detail

Summary

• Symbol: Unc5b^tm1.1Slac
• Name: unc-5 netrin receptor B; targeted mutation 1.1, Susan L Ackerman
• MGI ID: MGI:7338938
• Synonyms: Unc5B^fl, Unc5b^{tm1(flox)Slac}
• Gene: Unc5b Location: Chr10:60598373-60667360 bp, - strand Genetic Position: Chr10, 31.52 cM, cytoband B4
• Alliance: Unc5b^tm1.1Slac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328667
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked neomycin gene and second loxP site were inserted downstream of exon 5. The neomycin gene was removed via flp-mediated recombination leaving exon 6 floxed. (J:328667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc5b Mutation: 61 strains or lines available

References

• Original: J:328667 Boye K, et al., Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022 Mar 4;13(1):1169
• All: 1 reference(s)