Scn11aem1Smya
Endonuclease-mediated Allele Detail
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Symbol: |
Scn11aem1Smya |
Name: |
sodium channel, voltage-gated, type XI, alpha; endonuclease-mediated mutation 1, Shi-Ming Yang |
MGI ID: |
MGI:7341829 |
Synonyms: |
Nav1.9- |
Gene: |
Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
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Alliance: |
Scn11aem1Smya page
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Strain of Origin: |
Not Specified
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: CRISPR/Cas9 technology deleted 347 bp, staring in exon 3 and ending in exon 5, leading to a reading frame shift mutation followed by a premature translational-termination codon.
(J:329152)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Scn11a Mutation: |
87 strains or lines available
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Original: |
J:329152 Zu M, et al., SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves. BMC Neurosci. 2021 Mar 22;22(1):18 |
All: |
1 reference(s) |
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