Kcnc3^em1Jt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnc3^em1Jt
• Name: potassium voltage gated channel, Shaw-related subfamily, member 3; endonuclease-mediated mutation 1, Joseph S Takahashi
• MGI ID: MGI:7341848
• Synonyms: Kcnc3^G434V
• Gene: Kcnc3 Location: Chr7:44240088-44254178 bp, + strand Genetic Position: Chr7, 28.85 cM
• Alliance: Kcnc3^em1Jt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A G-to-T missense mutation (chr7:44,595,588, mm10) is introduced to exon 2 using CRISPR/cas9 methodologies and a gRNA targeting ACGCAGCCCCACGAAGTGACGG. The mutation resulted in a glycine-to-valine mutation (p.G434V). (J:327327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnc3 Mutation: 28 strains or lines available

References

• Original: J:327327 Xu P, et al., A missense mutation in Kcnc3 causes hippocampal learning deficits in mice. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2204901119
• All: 1 reference(s)