Tg(Rr280-EGFP)nPE2Mrub
Transgene Detail

Summary

• Symbol: Tg(Rr280-EGFP)nPE2Mrub
• Name: transgene insertion nPE2, Marcelo Rubinstein
• MGI ID: MGI:7343821
• Synonyms: nPE2-EGFP
• Transgene: Tg(Rr280-EGFP)nPE2Mrub Location: unknown
• Alliance: Tg(Rr280-EGFP)nPE2Mrub page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing region 9-13 kb upstream of the Pomc gene transcription start site with enhancer Rr279 deleted but Rr280 still present, and the Pomc gene, including 0.8 kb of upstream and 8 kb of downstream sequence, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The deleted region 0.8-9 kb upstream of Pomc contains pituitary enhancer Rr181. The transgene is expressed in hypothalamic arcuate neurons during embryonic development. (J:176451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:176451 Franchini LF, et al., Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15270-5
• All: 2 reference(s)