Dclk3^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dclk3^em1(IMPC)J
• Name: doublecortin-like kinase 3; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7344355
• Gene: Dclk3 Location: Chr9:111268149-111318186 bp, + strand Genetic Position: Chr9, 61.33 cM
• Alliance: Dclk3^em1(IMPC)J page
• IMPC: Dclk3 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CAGTCAACCCAGACGTCCAA and GTTTTGCTGTTGCAAGAGGG, which resulted in a 1922 bp deletion beginning at Chromosome 9 position 111,467,422 bp and ending after 111,469,343 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001026186 (exon 2) and 84 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 30 and early truncation 3 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dclk3 Mutation: 42 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)