Il17re^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Il17re^{tm1b(EUCOMM)Hmgu}
• Name: interleukin 17 receptor E; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7345521
• Gene: Il17re Location: Chr6:113435659-113447719 bp, + strand Genetic Position: Chr6, 52.76 cM
• Alliance: Il17re^{tm1b(EUCOMM)Hmgu} page
• IMPC: Il17re gene page

Mutation origin

• Mutant Cell Line: HEPD0908_3_B03
• Germline Transmission: Earliest citation of germline transmission: J:157065
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 113438419 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 113440144. The critical exon(s) is/are thus flanked by loxP sites. Flp expression without cre creates a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il17re Mutation: 36 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 1 reference(s)