Met^{tm2(MET*)Tcre}
Targeted Allele Detail

Summary

• Symbol: Met^{tm2(MET*)Tcre}
• Name: met proto-oncogene, receptor tyrosine kinase; targeted mutation 2, Tiziana Crepaldi
• MGI ID: MGI:7345548
• Synonyms: Ex14Del-ki
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^{tm2(MET*)Tcre} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Met^{tm2(MET*)Tcre} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MET (4233)

  Met	(MGI:96969)

  mutant human MET CDS (NM_000245.4; 4173 bp

• Mutation details: Ex14Del-ki mice harbour the "humanized" knock-in mutation of the human MET allele without exon 14 that replaces the mouse Met gene. The coding region of exon 3 plus partial intron 3 was replaced with the mutant human MET CDS without exon 14" (NM_000245.4; 4032 bp). C57BL/6N ES cells were used for gene targeting. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Met Mutation: 81 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)