Fga^em1Mjfk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fga^em1Mjfk
• Name: fibrinogen alpha chain; endonuclease-mediated mutation 1, Matthew J Flick
• MGI ID: MGI:7378190
• Synonyms: Fga²⁷⁰ line A
• Gene: Fga Location: Chr3:82933460-82940934 bp, + strand Genetic Position: Chr3, 36.96 cM, cytoband F1
• Alliance: Fga^em1Mjfk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced a premature termination codon (ACGT to TTAA change) in exon 5 at residue 271 to generate a truncation mutation in the alphaC region of fibrinogen. Plasma fibrinogen levels in homozygotes are approximately 10% of wild-type levels. The mutant fibrinogen is able to assemble into a mature fibrinogen molecule. Two lines, A and B were generated. Two lines, A and B were generated. This record represents line A. (J:330337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fga Mutation: 44 strains or lines available

References

• Original: J:330337 Hur WS, et al., Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation. Blood. 2022 Mar 3;139(9):1374-1388
• All: 1 reference(s)