Psen1^em2Tcs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Psen1^em2Tcs
• Name: presenilin 1; endonuclease-mediated mutation 2, Takaomi Saido
• MGI ID: MGI:7382956
• Synonyms: Psen1^P117L
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^em2Tcs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of proline with lysine at position 117 (P117L). (J:266488)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 46 strains or lines available

References

• Original: J:266488 Sasaguri H, et al., Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun. 2018 Jul 24;9(1):2892
• All: 2 reference(s)