Cdk19^em1Wehi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdk19^em1Wehi
• Name: cyclin dependent kinase 19; endonuclease-mediated mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:7388181
• Synonyms: Cdk19^D173A
• Gene: Cdk19 Location: Chr10:40225283-40359814 bp, + strand Genetic Position: Chr10, 21.94 cM
• Alliance: Cdk19^em1Wehi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated an aspartate to alanine substitution at amino acid 173, generating a kinase-dead allele. (J:331423)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk19 Mutation: 96 strains or lines available

References

• Original: J:331423 Dannappel MV, et al., CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. J Clin Invest. 2022 Oct 17;132(20):e158593
• All: 1 reference(s)