Cd4^{tm1(Cd8b1,Cd8a)Asin}
Targeted Allele Detail

Summary

• Symbol: Cd4^{tm1(Cd8b1,Cd8a)Asin}
• Name: CD4 antigen; targeted mutation 1, Alfred Singer
• MGI ID: MGI:7388565
• Synonyms: 8in4, Cd4(CD8)
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^{tm1(Cd8b1,Cd8a)Asin} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331514
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Cd4^{tm1(Cd8b1,Cd8a)Asin} expresses 2 genes
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd8a (MGI:88346)
  mouse	Cd8b1 (MGI:88347)

• Mutation details: The allele was generated by inserting a targeting vector into the translation start site in exon 2 of the gene. The target construct consisted of a TK cassette, Cd8b1 cDNA, IRES, Cd8a cDNA, a polyA sequence and floxed neomycin selection cassette. (J:331514)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 85 strains or lines available

References

• Original: J:331514 Shinzawa M, et al., Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nat Immunol. 2022 May;23(5):731-742
• All: 1 reference(s)