Ace2^em1Diam
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1Diam
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Michael S Diamond
• MGI ID: MGI:7398548
• Synonyms: Ace2^AGS63
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1Diam page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-cas9 mediated recombination created a 188 bp deletion surrounding the start codon in exon 2. (J:331773)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:331773 Winkler ES, et al., SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice. J Virol. 2022 Jan 12;96(1):e0151121
• All: 1 reference(s)