Rnh1^tm2.1Rall
Targeted Allele Detail

Summary

• Symbol: Rnh1^tm2.1Rall
• Name: ribonuclease/angiogenin inhibitor 1; targeted mutation 2.1, Ramanjaneyulu Allam
• MGI ID: MGI:7407148
• Synonyms: Rnh1^fl
• Gene: Rnh1 Location: Chr7:140740239-140752764 bp, - strand Genetic Position: Chr7, 86.44 cM
• Alliance: Rnh1^tm2.1Rall page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331827
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 10 and an FRT-flanked neomycin selection cassette and second loxP site were inserted upstream of exon 3. The neomycin cassette was removed via flp-mediated recombination in ES cells which express the flp recombinase, leaving exons 3-10 floxed. (J:331827)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnh1 Mutation: 25 strains or lines available

References

• Original: J:331827 Bombaci G, et al., LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Life Sci Alliance. 2022 Jun;5(6):e202101226
• All: 1 reference(s)