Tet3^tm1.2Jae
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1.2Jae
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1.2, Rudolf Jaenisch
• MGI ID: MGI:7408374
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1.2Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329181
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 4. The neomycin cassette was removed via flp-mediated recombination. Exon 4 was deleted via cre-mediated recombination. (J:329181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 59 strains or lines available

References

• Original: J:329181 Dawlaty MM, et al., Loss of Tet enzymes compromises proper differentiation of embryonic stem cells. Dev Cell. 2014 Apr 14;29(1):102-11
• All: 1 reference(s)