Hdac4^Slp2
Chemically induced Allele Detail

Summary

• Symbol: Hdac4^Slp2
• Name: histone deacetylase 4; sleepy2
• MGI ID: MGI:7412941
• Gene: Hdac4 Location: Chr1:91856501-92123421 bp, - strand Genetic Position: Chr1, 46.24 cM
• Alliance: Hdac4^Slp2 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced the A to T point mutation in the splice acceptor site resulting in exon skipping and loss of functional protein. (J:332227)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac4 Mutation: 110 strains or lines available

References

• Original: J:332227 Kim SJ, et al., Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature. 2022;612(7940):512-518
• All: 1 reference(s)