Sox10^tm1.1Heno
Targeted Allele Detail

Summary

• Symbol: Sox10^tm1.1Heno
• Name: SRY (sex determining region Y)-box 10; targeted mutation 1.1, Hideki Enomoto
• MGI ID: MGI:7414002
• Synonyms: Sox10^Venus
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^tm1.1Heno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A Venus-IRES-Sox10 cassette flanked by lox2272 and loxP followed by an FRT flanked neomycin cassette replaced the exon containing the Sox10 translation initiation codon in-frame. The neomycin cassette was removed via flp-mediated recombination. (J:320743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:320743 Uesaka T, et al., Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease. Glia. 2021 Nov;69(11):2575-2590
• All: 1 reference(s)