Gt(ROSA)26Sor^tm2Edb
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm2Edb
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Dieter Edbauer
• MGI ID: MGI:7414211
• Synonyms: PRstop, ROSA26 GFP-PR175
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm2Edb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324626
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, RMCE-ready, Reporter)
• Mutation: Insertion
• Mutation details: A construct containing a floxed-stop cassette followed by a CAG promoter driving expression of a GFP gene and sequence for a PR-175 dipeptide repeat protein encoded using non-repeating alternate codons was inserted into the cassette exchange locus in the Gt(ROSA)26Sor^tm1Rkuhn allele by recombinase mediate recombination. (J:324626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 958 strains or lines available

References

• Original: J:324626 LaClair KD, et al., Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020 Aug;140(2):121-142
• All: 1 reference(s)