Del(9Rr207839-Rr207840)9Vmc
Endonuclease-mediated Allele Detail
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Symbol: |
Del(9Rr207839-Rr207840)9Vmc |
Name: |
deletion, Chr 9, Vincent M Christoffels 9 |
MGI ID: |
MGI:7423617 |
Synonyms: |
RE6-8- |
Gene: |
Del(9Rr207839-Rr207840)9Vmc Location: unknown Genetic Position: Chr9, Syntenic
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Allele Type: |
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Endonuclease-mediated (Modified regulatory region) |
Mutation: |
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Intergenic deletion
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Del(9Rr207839-Rr207840)9Vmc involves 2 genes/genome features (Rr207839, Rr207840)
View all
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Mutation details: The super-enhancer between Exog and Scn5a, containing cardiac-specific Scn5a enhancers Rr207838, Rr207839 and Rr207840, was targeted with sgRNAs (targeting GGCACTATTTGAGTTCCACT and GGGAGCCGAGGGCGCTCCTT) using CRISPR/Cas9 technology, resulting in an ~9.9 kb deletion of the sequence containing Rr207839 and Rr207840.
(J:281596)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(9Rr207839-Rr207840)9Vmc Mutation: |
0 strains or lines available
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Original: |
J:281596 Man JCK, et al., An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Nat Commun. 2019 Oct 30;10(1):4943 |
All: |
1 reference(s) |
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