Tet2^em1Alfon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tet2^em1Alfon
• Name: tet methylcytosine dioxygenase 2; endonuclease-mediated mutation 1, Alfonso Gutierrez-Adan
• MGI ID: MGI:7427510
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^em1Alfon page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 3 deleted 11 bp. (J:332548)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 778 strains or lines available

References

• Original: J:332548 Martinez-Valiente C, et al., Aberrant Alternative Splicing in U2af1/Tet2 Double Mutant Mice Contributes to Major Hematological Phenotypes. Int J Mol Sci. 2021 Jun 28;22(13)
• All: 2 reference(s)