Trp73^tm1.1Gml
Targeted Allele Detail

Summary

• Symbol: Trp73^tm1.1Gml
• Name: transformation related protein 73; targeted mutation 1.1, Gerry Melino
• MGI ID: MGI:7429181
• Synonyms: Trp73^delta13
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^tm1.1Gml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291525
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed exon 13 required for expression of the alpha isoforms and inserted a selection cassette. Cre-mediated recombination removed exon 13 and prevented expression of the alpha isoforms. (J:291525)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 46 strains or lines available

References

• Original: J:291525 Amelio I, et al., The C terminus of p73 is essential for hippocampal development. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15694-15701
• All: 2 reference(s)