Mmp3^em1Vdb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mmp3^em1Vdb
• Name: matrix metallopeptidase 3; endonuclease-mediated mutation 1, Roosmarijn E Vandenbroucke
• MGI ID: MGI:7433081
• Gene: Mmp3 Location: Chr9:7445845-7455975 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Mmp3^em1Vdb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A guide RNA is designed to delete one base pair (T) in exon 4 (ENSMUSE00000215695 position 7,447,544 bp), in the catalytic domain of the gene. This mutation is predicted to cause amino acid sequence changes after residue 176 and a premature stop codon at position 327. (J:333090)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp3 Mutation: 32 strains or lines available

References

• Original: J:333090 Lefevere E, et al., Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury. Glia. 2020 Dec;68(12):2643-2660
• All: 1 reference(s)