Arc^tm1.2Kuhl
Targeted Allele Detail

Summary

• Symbol: Arc^tm1.2Kuhl
• Name: activity regulated cytoskeletal-associated protein; targeted mutation 1.2, Dietmar Kuhl
• MGI ID: MGI:7437803
• Synonyms: Arc/Arg3.1^f
• Gene: Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
• Alliance: Arc^tm1.2Kuhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269490
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The entire coding region was flanked by loxP sites. A neomycin resistance cassette and a third loxP site were inserted downstream of the second loxP site. The neomycin resistance cassette was removed via cre-mediated recombination leaving exons 1 and 2 floxed. (J:269490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arc Mutation: 26 strains or lines available

References

• Original: J:269490 Gao X, et al., Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12531-12536
• All: 1 reference(s)