Gsn^em2Crs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsn^em2Crs
• Name: gelsolin; endonuclease-mediated mutation 2, Caetano Reis e Sousa
• MGI ID: MGI:7443062
• Synonyms: Gsn^em2(sGsn)Crs
• Gene: Gsn Location: Chr2:35146392-35197904 bp, + strand Genetic Position: Chr2, 23.5 cM
• Alliance: Gsn^em2Crs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 produced a 43 bp deletion and 14 bp insertion mutation. This allele does not produce the soluble protein instead producing only the cytoplasmic version. (J:308614)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsn Mutation: 46 strains or lines available

References

• Original: J:308614 Giampazolias E, et al., Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity. Cell. 2021 Jul 22;184(15):4016-4031.e22
• All: 1 reference(s)