Irgm2^tm1.2Jcrs
Targeted Allele Detail

Summary

• Symbol: Irgm2^tm1.2Jcrs
• Name: immunity-related GTPase family M member 2; targeted mutation 1.2, Jorn Coers
• MGI ID: MGI:7444228
• Gene: Irgm2 Location: Chr11:58105803-58113609 bp, + strand Genetic Position: Chr11, 36.07 cM
• Alliance: Irgm2^tm1.2Jcrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301384
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted upstream of the start codon a loxP site and FRT-flanked neomycin resistance cassette. An additional loxP site was inserted downstream of the stop codon. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the coding region. (J:301384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irgm2 Mutation: 26 strains or lines available

References

• Original: J:301384 Finethy R, et al., Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020 Nov 5;21(11):e50830
• All: 2 reference(s)