Atf4^tm1.1Oyad
Targeted Allele Detail

Summary

• Symbol: Atf4^tm1.1Oyad
• Name: activating transcription factor 4; targeted mutation 1.1, Seiichi Oyadomari
• MGI ID: MGI:7444774
• Synonyms: Atf4^flox
• Gene: Atf4 Location: Chr15:80139385-80141742 bp, + strand Genetic Position: Chr15, 37.85 cM
• Alliance: Atf4^tm1.1Oyad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:333665)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf4 Mutation: 21 strains or lines available

References

• Original: J:333665 Kitakaze K, et al., ATF4-mediated transcriptional regulation protects against beta-cell loss during endoplasmic reticulum stress in a mouse model. Mol Metab. 2021 Sep 20;54:101338
• All: 2 reference(s)